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Effect of normal saline flush injection into a bronchus on lung decellularization

  
@article{JTD34046,
	author = {Masahiro Yanagiya and Kentaro Kitano and Takuma Yotsumoto and Daiya Takai and Hiromichi Asahina and Kazuhiro Nagayama and Jun Nakajima},
	title = {Effect of normal saline flush injection into a bronchus on lung decellularization},
	journal = {Journal of Thoracic Disease},
	volume = {11},
	number = {12},
	year = {2019},
	keywords = {},
	abstract = {Background: The aim of this study was to evaluate effect of normal saline flush injection into bronchus on creation of decellularized lung scaffolds.
Methods: Pigs were used: 3 lung grafts for decellularization with pre-treatment of normal saline injection into a bronchus, 3 for decellularization without pre-treatment and 3 treated as normal controls. We compared the characteristics of lung scaffolds created by each method.
Results: The pretreatment procedure significantly reduced the DNA content of lung grafts, suggesting effective removal of cellular components. However, this pretreatment also reduced the elastin contents of lung grafts.
Conclusions: Considering this characteristic of saline pretreatment, we must continue to look for better methods to produce ideal decellularized lung grafts.},
	issn = {2077-6624},	url = {https://jtd.amegroups.com/article/view/34046}
}