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Comparison of clinical features and polysomnographic findings between men and women with sleep apnea

	author = {Shiho Yamakoshi and Takatoshi Kasai and Yasuhiro Tomita and Hisashi Takaya and Satoshi Kasagi and Masateru Kawabata and Koji Narui and Yasuhiro Setoguchi},
	title = {Comparison of clinical features and polysomnographic findings between men and women with sleep apnea},
	journal = {Journal of Thoracic Disease},
	volume = {8},
	number = {1},
	year = {2016},
	keywords = {},
	abstract = {Background: There is a scarcity of reports comparing gender differences in polysomnographic findings among Asian patients with sleep apnea (SA). In this study, we elucidated gender differences in the clinical features and polysomnographic findings of SA patients in Japan.
Methods: We conducted a case-matched control study to compare the gender differences. A total of 4,714 patients (4,127 men; 587 women) were matched for age, apnea-hypopnea index (AHI), and body mass index (BMI). The criteria used for sex matching were (I) age ±4 years, (II) AHI ± 4 h of sleep, and (III) BMI ±2 kg/m2. This facilitated the comparison of polysomnography sleep variables in 296 men and 296 women with SA.
Results: Compared with their male counterparts, female SA patients had a significantly higher rapid eye movement AHI [men: 27.7 (IQR, 14.3-45.2); women: 43.3 (IQR, 25.5-56.6); P<0.001], lower supine AHI [men: 29.7 (IQR, 16.8-49.5); women: 25.0 (IQR, 14.7-39.3); P=0.004], longer total sleep time (TST), and non-rapid eye movement (NREM) sleep stage 3 (N3), %TST [TST in men: 356.3 (IQR, 319.5-392.3); women: 372.0 (IQR, 327.8-404.5); P=0.007; N3, %TST in men: 8.8 (IQR, 3.0-14.6); women: 14.4 (IQR, 8.3-20.4); P<0.001], and better sleep efficiency [men: 80.9 (IQR, 71.0-88.0); women: 83.2 (IQR, 74.5-90.0); P=0.011].
Conclusions: This study revealed that women with SA had a significantly longer TST and N3, %TST, which represents deep sleep. Future prospective studies must be conducted together with polysomnography tests including electromyography of pharyngeal muscle expansion and electroencephalography.},
	issn = {2077-6624},	url = {}