TY - JOUR AU - Gu, Zhitao AU - Fu, Jianhua AU - Shen, Yi AU - Wei, Yucheng AU - Tan, Lijie AU - Zhang, Peng AU - Han, Yongtao AU - Chen, Chun AU - Zhang, Renquan AU - Li, Yin AU - Chen, Keneng AU - Chen, Hezhong AU - Liu, Yongyu AU - Cui, Youbing AU - Wang, Yun AU - Pang, Liewen AU - Yu, Zhentao AU - Zhou, Xinming AU - Liu, Yangchun AU - Liu, Yuan AU - Fang, Wentao AU - Alliance for Research in Thymomas, Members of the Chinese PY - 2016 TI - Thymectomy versus tumor resection for early-stage thymic malignancies: a Chinese Alliance for Research in Thymomas (ChART) retrospective database analysis JF - Journal of Thoracic Disease; Vol 8, No 4 (April 01, 2016): Journal of Thoracic Disease [Thymic Malignancy—Perspectives from the Chinese Alliance for Research in Thymomas (ChART)] Y2 - 2016 KW - N2 - Background: To evaluate the surgical outcomes of tumor resection with or without total thymectomy for thymic epithelial tumors (TETs) using the Chinese Alliance for Research in Thymomas (ChART) retrospective database. Methods: Patients without preoperative therapy, who underwent surgery for early-stage (Masaoka-Koga stage I and II) tumors, were enrolled for the study. They were divided into thymectomy and thymomectomy groups according to the resection extent of the thymus. Demographic and surgical outcomes were compared between the two patients groups. Results: A total of 1,047 patients were enrolled, with 796 cases in the thymectomy group and 251 cases in the thymomectomy group. Improvement rate of myasthenia gravis (MG) was higher after thymectomy than after thymomectomy (91.6% vs . 50.0%, P vs . 1.4%, P=0.259). However in patients with Masaoka-Koga stage II tumors, recurrence was significantly less after thymectomy group than after thymomectomy (2.9% vs . 14.5%, P=0.001). Conclusions: Thymectomy, instead of tumor resection alone, should still be recommended as the surgical standard for thymic malignancies, especially for stage II tumors and those with concomitant MG. UR - https://jtd.amegroups.org/article/view/6962