@article{JTD7950,
author = {Francesco Guerrera and Claudio Mossetti and Manuela Ceccarelli and Maria Cristina Bruna and Giulia Bora and Stefania Olivetti and Paolo Olivo Lausi and Paolo Solidoro and Giovannino Ciccone and Enrico Ruffini and Alberto Oliaro and Pier Luigi Filosso},
title = {Surgery of colorectal cancer lung metastases: analysis of survival, recurrence and re-surgery},
journal = {Journal of Thoracic Disease},
volume = {8},
number = {7},
year = {2016},
keywords = {},
abstract = {Background: Surgery is considered an effective therapeutic option for patients with lung metastasis (MTS) of colorectal cancer (CRC). The purpose of the study was to evaluate efficacy and feasibility of lung metastasectomy in CRC patients and to explore factors of prognostic relevance.
Methods: This is a retrospective study of patients operated for lung MTS of CRC from 2004 to 2012 in a single Institution. Overall survival (OS) was the primary endpoint. Secondary endpoints were progression free survival (PFS) in resection status R0 and OS in in patients submitted to re-resections. In order to evaluate prognostic factors, a multivariable Cox proportional hazard model was performed.
Results: One-hundred eighty-eight consecutive patients were included in the final analysis. The median follow-up (FU) was 45 months. The 5-year OS and PFS were 53% (95% CI: 44–60%) and 33% (95% CI: 25–42%), respectively. Two- and 5-year survival after re-resection were 79% (95% CI: 63–89%) and 49% (95% CI: 31–65%), respectively. Multivariate adjusted analysis showed that primary CRC pathological TNM stages (P=0.019), number of resected MTS ≥5 (P=0.009) and lymph nodal involvement (P},
issn = {2077-6624}, url = {https://jtd.amegroups.org/article/view/7950}
}