@article{JTD88,
author = {Haihong Yang and Qi Zhang and Jianxing He and Wenju Lu},
title = {Regulation of calcium signaling in lung cancer},
journal = {Journal of Thoracic Disease},
volume = {2},
number = {1},
year = {2011},
keywords = {},
abstract = {Lung cancer is the most common malignant tumor in the world. Calcium is a ubiquitous cellular signal, which is crucial in cancer. This review presents regulation of calcium signaling in lung cancer. Altered expression of specific Ca2+ channels and Ca2+-binding proteins are characterizing features of lung cancer, which regulate cell signaling pathway leading to cell proliferation or apoptosis. Chemoresistance is frequent in lung cancer. Altered endoplasmic reticulum Ca2+ homeostasis of lung cancer cell is correlated with drug resistance. Hypoxia has a vital role in tumor angiogenesis, metastasis, apoptosis. And Ca2+ channels are open induced by hypoxia with the increase of Ca2+ influx causing tumor growth.},
issn = {2077-6624}, url = {https://jtd.amegroups.org/article/view/88}
}