Cough Section (Section Director: Peter Dicpinigaitis)

TRPV1 polymorphisms influence capsaicin cough sensitivity in men

Laura R. Sadofsky, Gerard Cantero-Recasens, Caroline Wright, Miguel A. Valverde, Alyn H. Morice


Capsaicin, the hot component of chilli peppers, is a well-known tussive agent, which is regularly used as a tool to study cough and antitussives (1). Capsaicin is known to activate the transient receptor potential vanilloid 1 (TRPV1) cation channel which is thought to be involved in pain perception, inflammation, itch and cough (2-4). These functions within the body make TRPV1 an exciting target for research and drug development.

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