A leopard can’t change its spots: can a T790M mutation-positive cancer change its spots after epidermal growth factor receptortyrosine kinase inhibitor therapy?

Kai Obayashi, Kimihiro Shimizu, Seshiru Nakazawa, Yoichi Ohtaki, Natsuko Kawatani, Ibe Takashi, Toshiki Yajima, Akira Mogi, Ken Shirabe


Drug therapies for non-small cell lung cancer (NSCLC) have greatly progressed in recent years. Especially, the identification of epidermal growth factor receptor (EGFR) mutation has transformed the management of patients with EGFR-mutant NSCLC, who are sensitive to EGFR tyrosine kinase inhibitor (EGFR-TKI).

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