Case Report

Complete response of 7 years’ duration after chemoradiotherapy followed by gefitinib in a patient with intramedullary spinal cord metastasis from lung adenocarcinoma

Yoshinobu Hata, Yujiro Takai, Hiroshi Takahashi, Keigo Takagi, Kazutoshi Isobe, Chikako Hasegawa, Kazutoshi Shibuya, Hidenori Goto, Kazuyoshi Tamaki, Fumitomo Sato, Hajime Otsuka


Intramedullary spinal cord metastasis is a rare but serious complication which causes rapid progression of neurological deficits. Here we report a 35-year-old man presenting with increasing leg pain and gait disturbance, 8 months after surgery for lung adenocarcinoma. Spinal magnetic resonance imaging revealed an intramedullary tumor at the Th7/8 level. Radiotherapy at 35 Gy resulted in transient symptomatic improvement, but during chemotherapy with vinorelbine and cisplatin, symptoms worsened again. Gefitinib was then administered; the patient improved after 2 weeks and has now maintained a complete response for 7 years.

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