Article Abstract

Novel insights and recent discoveries on the genetics and pathogenesis of malignant mesothelioma

Authors: Yin P. Hung, Lucian R. Chirieac


Malignant mesothelioma is a highly aggressive malignancy arising from the serosal lining. While most cases originate in the pleural lining of the thoracic cavity, a subset of cases primarily involves the peritoneum or, rarely, the pericardium or the tunica vaginalis (1). Studies have suggested that malignant mesothelioma comprises several clinicopathologic subgroups, with distinct site predilections and pathogenetic mechanisms.