Article Abstract

A richer understanding of intratumoral heterogeneity: single-cell genomics put it within reach

Authors: Xuetao Li, Jun Hou

Abstract

The advent of targeted therapeutics has brought unprecedented benefit to selected patients and pushed anticancer treatment shifting towards personalized and precise approaches (1). At the same time, their inherited limitations, mainly referring to acquired resistance, have largely increased our appreciation of intratumoral heterogeneity.