Article Abstract

Preoperative detrimental effect on cerebral function of severe congenital heart disease

Authors: Andrew C. Chatzis, Evangelia Grisbolaki


A growing body of evidence suggests that preoperative hypoxia in patients with congenital heart disease (CHD) has significant impact on subsequent postoperative outcomes (1) including, most importantly cerebral damage (2) and, yet not the least, myocardial (3,4) and renal dysfunction (5). Furthermore, the complexity, duration and number of surgical procedures required, constitute a considerable drawback for the developing brain. As a result the approach of complete repair in the neonatal period has been adopted in order to establish a normal circulation as soon as possible (6).