A case of sinobronchial syndrome progressing to diffuse panbronchiolitis despite low-dose, long-term macrolide therapy

Miki Abo, Yoshiaki Amino, Johsuke Hara, Noriyuki Ohkura, Takashi Sone, Hideharu Kimura, Kazuo Kasahara


Sinobronchial syndrome (SBS) is a disease involving chronic upper and lower airway inflammation caused by a decline in bronchial mucociliary transport or mucosal immunity. This article describes a case of refractory SBS that progressed despite macrolide therapy, and discusses the possible causes of the intractable nature of the disease.