Anesthesia and enhanced recovery in subxiphoid video-assisted thoracoscopic surgery
Review Article

Anesthesia and enhanced recovery in subxiphoid video-assisted thoracoscopic surgery

Zhigang Chen1#, Jason M. Ali2#, Huan Xu1, Lei Jiang1, Giuseppe Aresu2

1Department of Thoracic Surgery and Anaesthesia, Shanghai Pulmonary Hospital, Tongji University, Shanghai 200433, China; 2Thoracic Surgery, Royal Papworth Hospital NHS Foundation Trust, Papworth Everard, Cambridge, UK

Contributions: (I) Conception and design: All authors; (II) Administrative support: None; (III) Provision of study materials or patients: All authors; (IV) Collection and assembly of data: All authors; (V) Data analysis and interpretation: All authors; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors.

#These authors contributed equally to the work.

Correspondence to: Lei Jiang, MD. Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University, Shanghai 200433, China. Email: jiangleiem@aliyun.com.

Abstract: Subxiphoid video-assisted thoracoscopic surgery (VATS) is a surgical approach in minimally invasive thoracic surgery that aims to aid enhanced recovery by reducing postoperative pain by avoiding instrumentation of the intercostal spaces. Access through a subxiphoid port presents challenges for both the surgeon and anaesthetist. Particularly for left sided procedures, the heart can be compressed resulting in arrhythmia and haemodynamic compromise. The anaesthetic team play an important role in ensuring the success of subxiphoid VATS procedures. The key is continuous and comprehensive monitoring for circulatory disturbance and arrhythmia intraoperatively. Should arrhythmia develop it is important that it is managed rapidly and effectively in such a manner to minimize haemodynamic disturbance. In this article, important considerations for anaesthesia in subxiphoid VATS procedures is presented and solutions presented.

Keywords: Anaesthesia; subxiphoid; video-assisted thoracoscopic surgery (VATS); subxiphoid VATS (SVATS); enhanced recovery


Submitted Nov 08, 2018. Accepted for publication Nov 16, 2018.

doi: 10.21037/jtd.2018.11.90


Anaesthesia and enhanced recovery in subxiphoid video-assisted thoracoscopic surgery (VATS)

Thoracic surgery is evolving. A large thoracotomy is no longer the standard surgical access to the pleural cavity. VATS has become the norm and with it, improved patient outcomes and faster return to normal activity (1-3). However, VATS surgery is still associated with significant pain, and a risk of developing chronic pain due to instrumentation of the intercostal space. In an attempt to further improve outcomes in terms of pain and recovery from thoracic surgery a more recent development has been the use of the subxiphoid approach. In this approach, a vertical incision is made in the subxiphoid space and the pleural cavity is entered at this level (Figure 1). This approach then avoids any instrumentation of the intercostal spaces avoiding the potential for nerve compression and injury (4). To date, there has been one randomised controlled trial comparing subxiphoid VATS (SVATS) to standard VATS—in patients undergoing bullectomy and pleurectomy. They observed a significant reduction on postoperative pain in the SVATs group which was associated with earlier mobilisation and reduced risk of complication (5). The SVATS approach has become increasingly popular, and there are reports of a wide range of operations being performed from anatomical segmentectomies to pneumonectomies (6-15).

Figure 1 Subxiphoid access port for surgery with a patient in the right lateral decubitus position.

Thoracic surgery is usually performed in the context of well-developed enhanced recovery programs which further aids the benefit of the SVATS approach (16,17). However, SVATS presents certain perioperative challenges for the thoracic anaesthetic team. Particularly in left sided procedures, the patient’s heart may need to be displaced which can cause haemodynamic compromise and dysrhythmia.


Preoperative preparation

As for all surgical patients, pre-operative assessment is an important stage in preparation for surgery. Patients should be assessed by experienced thoracic anaesthetists with focus on documenting past medical history and performing physical examination. Basic laboratory investigations and pulmonary function tests are performed to ensure operability (18).

In the context of SVATS, the anaesthetic team should ensure additional attention is placed on assessing cardiovascular function. We would advocate that patients should have an electrocardiogram performed to assess for any dysrhythmia, and if there is any concern over cardiovascular function, echocardiography and exercise testing should be considered. In patients with compromised cardiovascular function, the operative approach should be reconsidered to minimize the risk to the patient (Table 1).

Table 1
Table 1 Contraindications for subxiphoid VATS surgery
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Intraoperative anaesthesia

Anaesthesia

The choice between total intravenous anaesthesia or combined anaesthesia should be determined by the preference and experience of the anaesthetic team. Anaesthesia should be induced, and patients intubated with a double-lumen endotracheal tube. The maintenance of sedation, analgesia and muscle relaxation during the surgery should the same as for standard VATS procedures.

Patient positioning

There are two commonly employed positions on the operating table for patients undergoing SVATS. To have adequate exposure of the subxiphoid region the patient needs to be tilted away from the lateral decubitus position. This can be achieved either by adjusting the angle of the operating table with the patient in the lateral decubitus position (Figure 2A) or positioning the patient tilted on the horizontal operating table (Figure 2B). It is important to pay attention during positioning of the patient to prevent injury to the brachial plexus and cervical spine—by preventing excessive head extension and/or rotation by using appropriate support devices.

Figure 2 Optimal patient positioning with the patient tilted away from the lateral decubitus position which can be achieved by either tilting the operating table (A), or tilting the patient (B).

Intraoperative monitoring

Standard monitoring should be performed including electrocardiogram, oxygen saturations, end-tidal CO2 and central temperature. For SVATS, we would advocate insertion of an arterial line and, especially in case of left sided procedures, central venous line in order that arterial blood pressure and central venous pressure can be monitored during the procedure, and blood gas analysis can be performed. These additional measures are employed to allow monitoring of the potential haemodynamic instability that can occur (19).

Intraoperative fluid management

Patients should receive intravenous fluid throughout the procedure, however they should be administered conservatively. In SVATS, occasionally there may be greater traction and compression of the lung parenchyma due to the challenging angles sometimes required to perform the surgery, which can lead to higher risk of lung injury and postoperative pulmonary oedema. The fluid strategy employed should also consider the duration of pre-operative dehydration the patient has experienced and be titrated to intraoperative cardiovascular monitoring and operative blood losses.

Ventilatory settings

A protective ventilation strategy should be utilized—with the aim of minimizing tidal volume (tidal volume of 6 mL/kg) with a low positive pressure (positive end expiratory pressure 5–10 cmH2O) (20). The benefit of this strategy is not only to minimize the risk of lung injury, but also there is a reduced oscillation of the mediastinum during single-lung mechanical ventilation. This aids surgical access by providing a stable and optimal space for the procedure which reduces the pressure of the surgical instruments on the heart.


Perioperative complications and their management

Arrhythmia

Due to the hearts position in relation to the subxiphoid access, arrhythmia is a frequent occurrence in SVATS—particularly in left sided procedures. The various surgical instruments are designed with angles to minimize cardiac interference, but some compression of the heart is inevitable and can result in a range of arrhythmias. The majority of encountered arrhythmias recover spontaneously and rapidly following temporary suspension of the surgery. Due to the location of the heart, the arrhythmias experienced in left sided procedures tend to be more severe and may result in hypotension.

A range of arrhythmias are encountered. The most benign arrhythmias experienced are single atrial (Figure 3A) or ventricular (Figure 3B) ectopic beats. Occasionally, ventricular ectopic beats are followed by an escape rhythm and a more sustained arrhythmia (for example, Figure 3C,D). It is also possible to observe a mixture of atrial and ventricular ectopics (Figure 3E), and occasionally patients will go into atrial fibrillation which can lead to hypotension (Figure 3F). It has also been observed for patients to develop ventricular tachycardia (Figure 3G).

Figure 3 Example arrhythmias experienced during subxiphoid VATS procedures. (A) Atrial ectopy, (B) ventricular ectopy, (C,D) ventricular ectopy leading to escape rhythms, (E) mixture of atrial and ventricular ectopy, (F) atrial fibrillation and (G) ventricular tachycardia. VATS, video-assisted thoracoscopic surgery.

The aim intraoperatively is to prevent haemodynamic compromise and/or progression of any arrhythmia experienced—aiming to reduce the frequency of ectopy and treat haemodynamic compromise experienced as a result of tachy/brady arrhythmias. The majority of arrhythmias experienced are easily reversed by pausing the surgery. Occasionally, it may be necessary to administer anti-arrhythmic drug treatment, although this does not need to be continued following the surgery. It may also be necessary to cardiovert a patient out of a rhythm such as atrial fibrillation—although this can be performed at the end of surgery with the patient supine unless there is an urgent need to treat the arrhythmia. If the patient becomes hypotensive then more aggressive management may be required and the surgery should be paused to allow for recovery and/or treatment to be administered—as this will then reduce the compression on the heart that likely is precipitating the arrhythmia. If the patient remains hypotensive then fluid resuscitation may be required, guided by the central venous pressure and the next step would be to consider introduction of vasoactive drug therapy. At this point, it would be advisable to convert from SVATS to a standard approach in order to safely complete the surgery.

Continuous monitoring of arterial blood pressure and electrocardiography is essential during SVATS in order that the anaesthetic team can remain vigilant to diagnose and respond rapidly to any arrhythmia and/or haemodynamic compromise that develops during the course of the procedure.

Hypoxemia

Similar to the situation in standard VATS, desaturation is a common problem faced by patients on single lung ventilation. The commonest problem is malposition of the double lumen tube due to migration. Other problems include ventilation/perfusion mismatch due to single lung ventilation and the lateral decubitus position and underlying pulmonary disease in the ventilated lung. A series of steps is recommended when facing desaturation during SVATS procedures (Table 2).

Table 2
Table 2 Management of patients desaturating during subxiphoid VATS surgery
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Postoperative extubation and analgesia

At the end of the surgery, two-lung ventilation is restored, and an airway pressure of 35 cmH2O is applied for 10 seconds as a lung recruitment manoeuvre. If muscle relaxant has been used and remains active, an anticholinesterase such as neostigmine can be administered as reversal. Once the patient regains consciousness and is able to maintain an airway, they can be extubated and transferred to the recovery room and eventually discharged to the ward.

Although the aim of SVATS is to minimize the postoperative pain incited, it is essential that pain management is optimized as after all surgery to observe the maximal benefit and facilitate enhanced recovery. A range of approaches is adopted but usually includes combination of intravenous analgesia and regional nerve blocks, for example thoracic epidural or more commonly, paravertebral infusions (21,22). Adequate antiemetic should be prescribed in order to minimize the complications associated with opiate analgesia. For patients with a history of vomiting or vertigo, the preventive use of dexamethasone and reducing intraoperative related drugs can be advantageous in preventing vomiting and nausea.

An example post-operative analgesia protocol that is utilized in Shanghai Pulmonary Hospital, China, is presented in Table 3. It has been designed to reduce the rate of complications and accelerate mobilization of the patient following surgery.

Table 3
Table 3 Example postoperative analgesia protocol to facilitate enhanced recovery following subxiphoid VATS procedures
Full table

Summary

Subxiphoid VATS is a recent development in thoracic surgery that aims to aid enhanced recovery by reducing postoperative pain. The anaesthetic team play an important role in ensuring the success of these surgeries. The key is continuous and comprehensive monitoring for circulatory disturbance intraoperatively. Should arrhythmia develop it is important that it is managed rapidly and effectively in such a manner to minimize haemodynamic disturbance.


Acknowledgements

None.


Footnote

Conflicts of Interest: The authors have no conflicts of interest to declare.


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Cite this article as: Chen Z, Ali JM, Xu H, Jiang L, Aresu G. Anesthesia and enhanced recovery in subxiphoid video-assisted thoracoscopic surgery. J Thorac Dis 2018;10(12):6987-6992. doi: 10.21037/jtd.2018.11.90