Article Abstract

Values of fractional exhaled nitric oxide for cough-variant asthma in children with chronic cough

Authors: Jing Zhou, Xianhong Zhao, Xu Zhang, Xingmei Yu, Yuqing Wang, Wujun Jiang, Li Huang, Chuangli Hao, Luo Zhang

Abstract

Background: Chronic cough is a common symptom in children. We wished to explore the value of fractional exhaled nitric oxide (FeNO) for cough-variant asthma (CVA) in children with chronic cough.
Methods: This prospective cohort study was conducted in the Children’s Hospital of Soochow University from January 2012 to December 2014. Children aged 6–14 years with a cough of duration >4 weeks were enrolled. They underwent FeNO measurement, sputum cytology and pulmonary function tests.
Results: A total of 115 patients and 25 healthy controls were evaluated. For the diagnosis of CVA, the optimal FeNO cutoff value was 25 ppb with a sensitivity of 84.0%, specificity of 97.1%, positive predictive value of 97.5%, and negative predictive of being 81.4%. The FeNO level had a significant correlation with eosinophil count in sputum (P<0.05). FeNO level in CVA was decreased significantly after treatment (P=0.001).
Conclusions: In children, FeNO measurement might be an excellent method for diagnosing CVA with high sensitivity and specificity.

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