MRI-guided segmental sternectomy for impalpable intraosseous lesion
Surgical Technique

MRI-guided segmental sternectomy for impalpable intraosseous lesion

Francesco Petrella1,2, Monica Casiraghi1, Niccolò Filippi1, Riccardo Orlandi1, Andrea Alliata1, Giorgio Lo Iacono1, Luigi Funicelli3, Stefania Rizzo4, Lorenzo Spaggiari1,2

1Department of Thoracic Surgery, IRCCS European Institute of Oncology, Milan, Italy; 2Department of Oncology and Hemato-oncology, University of Milan, Milan, Italy; 3Department of Radiology, IRCCS European Institute of Oncology, Milan, Italy; 4Department of Radiology, EOC-Institute of Imaging of the Italian Switzerland, Lugano, Switzerland

Correspondence to: Francesco Petrella, MD, PhD. Department of Thoracic Surgery, European Institute of Oncology - Via Ripamonti, 435, Milan, Italy. Email: francesco.petrella@ieo.it; francesco.petrella@unimi.it.

Submitted Jul 15, 2019. Accepted for publication Jul 22, 2019.

doi: 10.21037/jtd.2019.07.91


Introduction

The sternum is an uncommon site for neoplastic lesion and so sternectomy for oncologic indications is rare (1,2). Primary tumors of the sternum represent 0.5% of all primary bone neoplasms, being chondrosarcoma the most frequent, occurring mainly in young male patients (3). The sternum can be the site of isolated bone metastasis from non-bone primary tumors and sternectomy can be indicated in very selected case.

Usually resection of the sternum is limited to surgical treatment of infections complicating cardiac and thoracic operations: in this case infection treatment and chest wall stability are the main goal (4); on the contrary, when radical resection is required for oncologic reasons, wide margins need to be obtained and chest wall reconstruction may require prosthetic devices and its coverage by adequate muscle flaps (5).

Here we report a case of undiagnosed, increasing 68Gallium positron emission tomography (PET) positive lesion of the upper third of the sternal body in patient with a past history of a resected, well-differentiated, neuroendocrine tumor of the right colon in which computed tomography (CT) guided sternal biopsy was attempted but without any diagnoses.

Segmental sternectomy was planned for diagnostic and therapeutic approach.


Surgical technique

A 55-year-old male patient with a previous clinical history of a resected, well-differentiated, neuroendocrine tumor of the right colon was referred to our department because of an increasing 68Gallium PET positive lesion of the upper third of the sternal body (Figure 1). Magnetic resonance imaging (MRI) confirmed the focal lesion 11 mm in diameter within the body of the sternum (Figure 2), while CT scan did not disclose any findings.

Figure 1 Preoperative 68Ga PET scan.
Figure 2 Preoperative magnetic resonance imaging disclosing intraosseous lesion of the upper third of the sternal body (red arrow).

A CT guided needle biopsy was attempted—on the basis of MRI and PET findings—but without any histologic results (Figure 3). After a multidisciplinary meeting, the need of a clear histology of the increasing sternal lesion was confirmed; the patient was then submitted to segmental sternectomy under MRI guidance.

Figure 3 CT-guided biopsy attempt, without any histologic results.

Preoperative MRI allowed to identify the target lesion and to mark its projection on the skin.

Segmental sternectomy—involving the upper third of the sternal body and 2nd and 3rd sterno-chondral articulations on both sides was performed; chest wall reconstruction was performed by a polypropylene mesh/methylmethacrylate composite prosthesis that was then covered by a bilateral flap of pectoralis major muscles (Figure 4). Postoperative course was uneventful and the patient was discharged in good clinical conditions on postoperative day 6.

Figure 4 MRI-guided segmental sternectomy, reconstruction by polypropylene mesh/methylmethacrylate composite prosthesis and double pectoralis major muscle flap (6). Available online: http://www.asvide.com/watch/33069

Discussion

Unpalpable intraosseous lesions to be resected still represent a major challenge for thoracic surgeons: in fact, inappropriately placed skin incisions, incomplete tumor excision or wrong segment resection may happen (7). Thanks to recent advancements, many focal bone lesions can be preoperatively detected by CT and PET scan (8) and marked by radioisotope injection.

On the contrary, complete intraosseous sternal lesion, not visible by CT scan, may represent a further challenge and MRI guide represents the ideal tool for an effective and precise preoperative mark.

Basic principles of segmental sternectomy are bilateral mammary vessels isolation and ligation above and below the interested segments as well as intercostal vessels ligation of the involved sterno-chondral articulations. Although many techniques and devices have been described for sternal reconstruction—ranging from basic prosthesis to sternal cadaveric allograft to 3D printing (9-12)—we still consider a polypropylene mesh/methylmethacrylate composite prosthesis one of the most suitable device. Adequate prosthesis coverage by wide muscular flaps is mandatory and bilateral pectoralis major muscle flaps can be considered the most appropriate if soft tissue resection is not required; on the contrary—if pectoralis muscles are involved by neoplastic tissue—latissimus dorsi muscle flap represents the best available option.


Acknowledgments

None.


Footnote

Conflicts of Interest: The authors have no conflicts of interest to declare.

Ethical Statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. The patient was informed that his clinical data could be used for various clinical studies, and written informed consent was obtained on this basis.


References

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Cite this article as: Petrella F, Casiraghi M, Filippi N, Orlandi R, Alliata A, Lo Iacono G, Funicelli L, Rizzo S, Spaggiari L. MRI-guided segmental sternectomy for impalpable intraosseous lesion. J Thorac Dis 2020;12(1):42-44. doi: 10.21037/jtd.2019.07.91