Role of proximal and distal tear size ratio in hemodynamic change of acute type A aortic dissection
Original Article

Role of proximal and distal tear size ratio in hemodynamic change of acute type A aortic dissection

Xiaonan Li1, Huanyu Qiao1, Yue Shi2, Jinrong Xue1, Tao Bai1, Yongmin Liu1, Lizhong Sun1

1Department of Cardiovascular Surgery, Beijing Anzhen Hospital of Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China; 2School of Life Science and BioEngineering, Beijing University of Technology, Beijing, China

Contributions: (I) Conception and design: X Li, Y Liu, L Sun; (II) Administrative support: Y Liu, L Sun; (III) Provision of study materials or patients: J Xue, T Bai; (IV) Collection and assembly of data: X Li, H Qiao, Y Shi; (V) Data analysis and interpretation: X Li; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors.

Correspondence to: Yongmin Liu. Department of Cardiovascular Surgery, Beijing Anzhen Hospital, Capital Medical University, No. 2 Anzhen Road, Beijing, China. Email:; Lizhong Sun. Department of Cardiovascular Surgery, Beijing Anzhen Hospital, Capital Medical University, No. 2 Anzhen Road, Beijing, China. Email:

Background: Acute type A aortic dissection (ATAAD) is a life-threatening disease. The aim of this study was to examine the role of tear size in the hemodynamic change and help improve the treatment level of this extremely dangerous disease.

Methods: A total of 120 ATAAD patients treated in our institution from November 2014 to December 2016 were divided into three groups according to proximal and distal tear size ratio (PDTSR). There were 35 patients in group A (PDTSR ≥2:1), 44 patients in group B (1:2< PDTSR <2:1), and 41 patients in Group C (PDTSR ≤1:2). Three computational fluid dynamics (CFD) models with different PDTSRs were established to investigate the hemodynamic difference in the three groups.

Results: The mean age (± SD) of the 120 patients included in this study was 47.7±10.1 years. Patients in Group A had a significantly larger proximal tear size (219.1±76.5 vs. 127.7±70.1 vs. 75.7±49.7 mm2; P<0.001). The mortality of the patients in group A was significantly higher than those in group B and group C in the acute phase (37.1% vs. 2.3% vs. 2.4%, respectively; P<0.001). A proximal tear larger than a distal tear was found to be significantly associated with preoperative death in logistic regression analysis (odds ratio: 15.89; 95% confidence interval, 2.702–93.477; P=0.002).

Conclusions: A proximal tear larger than a distal tear was associated with a significantly high-pressure difference between false and true lumens and more blood flow into the false lumen. In such cases, patients would experience extremely high mortality and morbidity.

Keywords: Acute type A aortic dissection (ATAAD); proximal tear size; distal tear size; computational fluid dynamics (CFD)

Submitted Apr 20, 2020. Accepted for publication Jun 04, 2020.

doi: 10.21037/jtd-20-1920


Acute type A aortic dissection (ATAAD) is a life-threatening condition for which early diagnosis, treatment, and close follow-up are critical for survival. The mortality rate of untreated ATAAD reaches 50% in the first 48 hours, and immediate surgical intervention is indicated after the diagnosis (1-4). Within the last decades, techniques for complete aortic root replacement were applied and more recently aortic valve sparing root surgery (for example David and Yacoub technique) was introduced in ATAAD repair. Furthermore, synthetic vascular grafts with side branches and hybrid prosthesis have been evolved as reliable solutions for the dissected aortic arch and descending aorta. However, the clinical manifestations and complications of ATAAD are protean, with multisystem involvement and a range of severity; therefore, not all patients can receive surgery in time.

As far as we know, hemodynamic forces play an important role in the pathogenesis of aortic dissection. Several studies have pointed out that ATAAD patients experience an extremely high operative mortality once hemodynamic instability emerges which is similar to what occurs with medical management alone (5-7). Although most hemodynamic parameters cannot be measured directly, the recent development of computer technology has enabled computational fluid dynamics (CFD) to be widely applied in the study of hemodynamics and has provided a novel way to elucidate the mechanism of aortic dissection. Several studies have reported that blood flow into the false lumen and false lumen pressure increase with the greater size of the primary tear (8,9). Although these numerical models could help us understand the relationships between the risks and tear size, the issue still needs clinical data validation to solve the practical clinical problems.

To our knowledge, no studies have investigated the role of tear size by correlating the CFD findings with clinical data of ATAAD. We believe both the proximal and distal tear size should be taken into consideration in evaluating the perioperative outcomes and hemodynamic changes. The purpose of our research was to summarize the clinical data of ATAAD patients with CFD simulation to verify the effectiveness of CFD and help explain the various clinical manifestations of ATAAD patients to improve the treatment level. We present the following article in accordance with the STROBE reporting checklist (available at



The study was conducted in accordance with the Declaration of Helsinki and was approved by the Beijing Anzhen Hospital of Capital Medical University (KS2019034) and written informed consent was obtained from all patients.

Patients with the radiologic diagnosis of ATAAD from November 2014 to December 2016 in our institution were identified. The diagnosis of ATAAD was established with computed tomography angiography (CTA) examinations after the onset of symptoms. According to the Stanford University classification, type A aortic dissection was defined as an involvement of the ascending thoracic aorta and/or the aortic arch. Aortic dissection was defined as acute if chest pain and/or related symptoms were present within 14 days of the operation (1). CTA was performed with 64-slice scanners with intravenous injection of 80 to 120 mL of nonionic iodinated contrast material. Furthermore, the image was required to be clear enough for the measurement of aortic parameters, such as tear sizes and diameters of dissection, and those that were not were excluded. Patients only affected by the ascending aorta were excluded. Preoperative clinical variables were recorded, including patient demographics and history, clinical presentation, complications and mortality, and imaging results.

All procedures were carried out by a median sternotomy and total cardiopulmonary bypass (CPB) with selective cerebral perfusion (SCP). Cannulation of the right axillary artery was used for CPB and SCP. The arterial line was bifurcated for the right axillary artery and for antegrade perfusion through 1 limb of a 4-branch prosthetic graft. Aortic root procedures were done (if indicated) during cooling. Circulatory arrest was instituted if the nasopharyngeal temperature reached 18 to 22 °C. Unilateral SCP was started through the right axillary artery after the brachiocephalic arteries were cross-clamped and the brain was perfused.

Image analysis

To decrease the selection bias, CT images were evaluated by two experienced cardiac surgeons with >10 years of experience (Dr. Liu and Dr. Sun). Intimal tears were detected and measured at axial and sagittal views with CTA which scanned the entire aorta and the product of two diameters stands for the tear size (shown in Figure 1). Patients who had multiple proximal or distal tears were represented by the sum of the sizes. Patients were divided into three different groups according to the proximal and distal tear size ratio (PDTSR). Patients whose PDTSR was ≥2:1 were defined as group A, patients whose PDTSR was between 1:2 and 2:1 were defined as group B, and patients whose PDTSR was ≤1:2 were defined as group C.

Figure 1 Measurement of tear (arrow) size. (A) Diameter at axial view; (B) diameter at sagittal view.

Numerical model creation

The numerical model of the aorta dissection was established based on the CTA data of a normal aorta. A semi-automatic threshold-based segmentation tool (Mimics17.0, Materialise Inc., Belgium) was used to complete the image segmentation and surface reconstruction of the normal aorta. The models were exported into the stereolithographic (STL) file format after smoothing. The format of aorta models was changed into X_T by using the exact surface function (Geomagic Wrap 2015, Geomagic Inc., USA). Starting from the middle of the ascending aorta to the end of the thoracic aorta, a thin 1.2-mm thick layer was cut from the aorta model along the aorta axis to be used as the dissection flap. The modification of tear size and location was performed using an extruded boss feature and a computer-aided design (CAD) tool (SolidWorks 2015, SolidWorks Inc., France). The final models are shown in Figure 2. The proximal and distal tear sizes of three models were set according to the CT measurement results which are shown in Table 1.

Figure 2 Three Stanford type A aortic dissection digital models of different proximal and distal tear sizes: model A, model B, and model C stand for group A, group B, and group C, respectively.
Table 1
Table 1 Preoperative patient data
Full table

Meshing and elements

A semi-automatic adaptive meshing technique was employed in HyperMeshv10.0 (Altair HyperWorks, Troy, MI, USA) to optimize both computational efficiency and element quality. Four-noded tetrahedral elements were assigned to all models, and the element size was set to 0.001 m. The grid was divided into various entrances, exits, and intimal regions.

Boundary conditions and flow models

The Navier-Stokes equations were solved numerically with a commercial finite-volume-based CFD solver (Fluent 15.0, Ansys, Inc., USA). Transient analysis was adopted to investigate the pulsatility of blood flow. Inlet flow waveforms for the ascending aorta were based on data presented by Mills et al. (10). The time-dependent pulsatile waveforms of flow at the descending aorta outlet, the brachiocephalic artery outlet, the left subclavian artery outlet, and the left common carotid artery outlet were obtained from the work of Olufsen et al. (11). We considered the blood to be incompressible and to have the same kinematic viscosity and density of Newtonian fluid with a dynamic viscosity of 3.5 m Pa and a density of 1,050 kg/m3. The aortic wall was assumed to be rigid, and therefore a no-slip condition was applied to the aortic wall. The calculation time-step and cardiac cycle were set to 0.01 and 0.8 seconds, respectively. The maximum root mean square residual was set as 10−5, and the maximum number of iterations per time step was set to 200 to ensure sufficiently accurate results. To minimize the influence of initial flow conditions, all simulations were carried out for 4 cardiac cycles to achieve a periodic solution, and the results presented here were obtained in the fourth cycle.

Statistical analysis

Continuous variables are reported as mean and standard deviation, and categorical data are reported as count and percentage. The t-test was selected to compare the differences between two groups in continuous variables. Pearson’s χ2 test and Fisher’s exact test were selected to compare the differences in categorical variables between the three groups. We conducted binary logistic regression analysis to investigate the risk factors for the pre-operative death of ATAAD patients; P values <0.1 in univariate Analysis were input into multivariate analysis. In all tests, a P value <0.05 was considered significant. All calculations were performed using SPSS 25.0 (IBM Corporation, Chicago, USA).


Clinical data

During the period from November 2014 to December 2016, 120 patients who were diagnosed with ATAAD based on an initial CTA scan performed at our institution were selected. Many other patients were transferred to our institution on the basis of CTA images; as these initial scans were not readily available for measurement of the tear sizes, these patients were not included in this study. According to the ratio of proximal and distal tear size, 35 patients were included in group A, 44 patients in group B, and 41 patients in group C.

The preoperative clinical characteristics of ATAAD patients are summarized in Table 1. The mean age (± SD) of the 120 patients in this study was quite young (47.7±10.1 years). The majority of patients (69.1%) were male, and most patients (77.5%) had a history of hypertension. In our study, 8 patients had Marfan syndrome which is a multisystem connective tissue disorder with primary involvement of the cardiovascular, ocular, and skeletal systems. In group A, the patients had a significantly larger proximal tear (219.1±76.5 vs. 127.7±70.1 vs. 75.7±49.7 mm2; P<0.001). While the distal tear sizes were smaller in group A (71.9±43.2 vs. 114.1±60.6 vs. 131.3±70.4 mm2; P=0.001), other variables were generally similar between the three groups.

Of the 120 patients, 15 patients died before the surgery, while the other 105 patients received emergency surgeries. The pre-operative mortality of patients in group A was significantly higher than that in group B and group C in the acute phase (37.1% vs. 2.3% vs. 2.4%, respectively; P<0.001). At the same time, the complication rate was higher in Group A, though this difference was not significant according to Pearson’s χ2 test (37.1% vs. 18.1% vs. 26.8%, respectively; P=0.171). Pre-operative mortality and complications are shown in Table 1.

All 105 patients underwent total arch replacement, 47 patients underwent the Bentall procedure, and 58 patients underwent ascending aorta replacement. Furthermore, 12 patients died within 30 days after the surgery (3 vs. 4 vs. 5, respectively; P=0.319). The rate of ventilator support lasting >5 days was significantly higher in group A (50% vs. 18.6% vs. 17.5%; P=0.006). Closure rate of the false lumen 3 months after the surgery was also higher in Group A, but the difference was not significant (85% vs. 65% vs. 72.7%, respectively; P=0.263). Perioperative data are shown in Table 2.

Table 2
Table 2 Operative data and postoperative outcomes
Full table

We also analyzed the predictors of preoperative death of ATAAD patients (Table 3). Proximal tear size larger than the distal tear was significantly associated with preoperative death of the ATTAAD patients in multivariate analysis [odds ratio (OR): 15.89; 95% confidence interval (CI), 2.702–93.477; P=0.002].

Table 3
Table 3 Predictors of preoperative death
Full table

Numerical simulation

Flow patterns

Velocity at peak systole data are presented in Figure 3A. In the true lumen, turbulence of flow appeared near the aortic arch in all models. The same situation was observed in the false lumen, and the vortex phenomenon became more significant when the blood flow rate became lower. This phenomenon was similar to blood flow patterns observed in previous studies (12). In the whole pulse period, the blood flow velocity of the true lumen was faster than that in the false lumen. When the blood flowed from the aortic arch to the descending thoracic aorta, the peak value of the velocity gradually deviated from the medial wall, and the velocity was found to accelerate when passing through proximal and distal tears.

Figure 3 Flow velocity maps, wall pressure, and TAWSS on the intima at systolic peak: (A) flow velocity maps of the three models; (B) TAWSS contour plots of the intima of the three models; (C) pressure distributions at systolic peak. TAWSS, time-averaged shear stress.

The flow rate of the false lumens was significantly different between the three models. With a large proximal tear and a small distal tear, blood flow in the false lumen was much greater in model A than that in model B and model C (42.98% vs. 29.23% vs. 26.63%). This would lead to a trend of continual expansion of the dissection and compression on the true lumen (13,14).

Time-averaged shear stress (TAWSS)

TAWSS is obtained by averaging the wall shear stress in a cardiac cycle. The distribution is shown in Figure 3B, and the three models do not differ from each other very much. TAWSS gradually decreases from the ascending aorta to the distal end and partially elevates around the intimal tears. The wall TAWSS of the true and false lumen varies greatly throughout the cardiac cycle, and the TAWSS in the true lumen is higher than that in the false lumen and has a greater variation range.

Pressure distribution

The pressure distribution of the aortic wall at peak systole is shown in Figure 3C. The wall pressure gradually decreased from the ascending aorta to the distal end. Furthermore, the high wall pressure of ascending aorta and proximal descending aorta indicates that these sites may be dangerous areas of rupture. The false lumen wall pressure of both models was consistently higher than that of the true lumen. Figure 4 shows the pressure difference of the two sides along the intima. When the pressure difference was significantly higher in model A, which had a larger proximal tear, the true lumen in model A would be compressed more seriously. This helps explain the higher mortality and morbidity in the group A patients. Continuous compression on the intimal wall may lead to structural damage and the stiffness and elasticity changes of the aortic wall, and eventually worsen the prognosis of patients. At the same time, the wall pressure difference changed considerably along the intima and showed a strong pulsation. The shrinking and stretching of the intima to adapt to the pressure changes would cause the emergence of re-entry tears.

Figure 4 Pressure difference between the false and true lumen at systolic peak (Pa): Line 1: true lumen side of intima; Line 2: false lumen side of intima; (A) pressure difference in model A; (B) pressure difference in model B; (C) pressure difference in model C. Ordinate represents the intimal length, and abscissa represents the pressure difference (false lumen pressure–true lumen pressure).


ATAAD results from a tear in the aortic intima, which allows a pressurized hematoma to form within the media between the inner two-thirds and outer one-third of the aorta. The blood typically propagates rapidly along the length of the aorta and often compromises branch vessels along its path. The intimal tear plays a crucial role in the occurrence and progress of ATAAD, and the main purpose of open surgery is to exclude the intimal tears (14-16). It was reported that type B aortic dissention patients with entry tear size ≥10 mm presented a higher incidence of dissection-related events and median growth rate than those with entry tear size 10 mm (17). Experimental studies have shown that a larger entry tear and inadequate outflow from the false lumen in type B aortic dissection would lead to a significant increase in mean arterial and diastolic pressure (9). However, all these studies focused on type B aortic dissection, which had better in-hospital survival than type A aortic dissection in the acute phase, and there was a paucity of studies investigating the hemodynamic changes in ATAAD patients. The incidence of type A aortic dissection was higher than type B aortic dissection, and patients with type A aortic dissection suffer double the mortality of individuals presenting with type B aortic dissection (25% and 12%, respectively) (1). Thus, our study aimed to investigate the role of PDTSR in hemodynamic changes of ATAAD patients by combining the CFD simulation with clinical data.

According to Mehta et al., abrupt onset of chest pain, hypotension, shock, and tamponade have been demonstrated to be predictors of in-hospital death in ATAAD patients (18). However, the morphologic cause of these complications still remains unknown. Our study collected the preoperative data of ATAAD patients with different PDTSR, and the results showed that patients whose proximal tear was larger than their distal tear would experience a significantly higher mortality and morbidity. The results of CFD gave us a better understanding of the clinical data and helped us to understand the hemodynamic changes of ATAAD patients. Patients with a larger proximal tear (model A) experienced a higher pressure difference between the false and true lumen and a higher percentage of total aortic flow diverted into the false lumen. In this case, the false lumen continued to expand, and the patients were more prone to persistent chest pain and severe complications. To decrease the compression on true lumen and avoid aortic rupture, patients with a larger proximal tear may need stricter antihypertensive therapy during the perioperative period and more urgent surgical treatment. Moreover, we also noticed that the number of patients in group A was apparently smaller than that of group B and C. This indicates that patients with larger proximal tears were less likely to survive before arriving at the emergency room because of the early emergence of hemodynamic instability and sudden aortic rupture.

Wall shear stress has been implicated in initial aneurysm formation (19), but its role in aneurysmal pathogenesis and evolution is unclear. Aortic and intracranial aneurysm growth has been seen in both low wall shear stress conditions and high wall shear stress conditions (20-22). In the present study, high TAWSS was observed in both models from the ascending aorta to the proximal descending aorta, with the change of tear size having no impact. High TAWSS in the ascending aorta may be the reason why type A aortic dissection accounts for a significant proportion of aortic dissections (23,24).

Patients in group B and C were relatively more stable than those in group A during the preoperative period. We found out that it was the PDTSR, and not just the size of proximal or distal tear size, that decided the clinical outcomes of the patients. Consequently, patients whose proximal tear is larger than their distal one would benefit more from emergency surgery in order to avoid preoperative hemodynamic instability and aortic rupture. We also noticed that the 3-month closure rate of the false lumen was higher in group A (85% vs. 65% vs. 72.7%, respectively; P=0.263), though the difference was not significant. In the postoperative period, the large distal tears turned into entry tears, which would led to more blood flow being diverted into the false lumen, and in this way the false lumen would stay patent in the follow-up time. We speculate that the remaining large distal tears of patients in group B would lead to a patent or partial false lumen during the post-operative follow-up period which has been demonstrated to be related to unfavorable prognosis after surgical repair (14,16,17,25,26). In this case, those patients with larger proximal tears (group A) may benefit from early intervention and develop the prognosis avoid re-operation, although this speculation requires further confirmation by further study.

Some limitations to this research should be addressed. First, the aortic wall was assumed to be rigid and the deformation of vessel was ignored. Second, as the source of dissection geometry was CTA imaging, both models were subjected to identical inflow and outflow conditions. Although magnetic resonance angiography may provide more hemodynamic parameters, CTA remains the most common diagnostic imaging type performed in most type A aortic dissection patients. Third, the pixel widths of CT scans were not exactly the same, so some small tears might not have been detected. Finally, as not all CTAs were clear enough and most patients were transferred without initial CTA data making a measurement of the tear size impossible, our cohort size was relatively small.


A proximal tear significantly larger than a distal tear was associated with significantly different pressure difference between the false and true lumens and more blood flow into the false lumen. In this case, patients would experience extremely high mortality and morbidity and benefit from urgent surgery to fix the aortic dissection. These preliminary results demonstrated that computational aortic flow simulations can be used to clarify the pathogenesis of aortic dissection and help predict the clinical outcomes of ATAAD.


Funding: This work was funded by the Beijing Municipal Science & Technology Commission (Grant No. Z191100006619094).


Reporting Checklist: The authors have completed the STROBE reporting checklist. Available at

Data Sharing Statement: Available at

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at The authors have no conflicts of interest to declare.

Ethical Statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. The study was conducted in accordance with the Declaration of Helsinki and was approved by the Beijing Anzhen Hospital of Capital Medical University (KS2019034) and written informed consent was obtained from all patients.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See:


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Cite this article as: Li X, Qiao H, Shi Y, Xue J, Bai T, Liu Y, Sun L. Role of proximal and distal tear size ratio in hemodynamic change of acute type A aortic dissection. J Thorac Dis 2020;12(6):3200-3210. doi: 10.21037/jtd-20-1920