AB 56. Combined large cell neuroendocrine CA with
squamous cell CA of the lung
Background: Presentation of a rare case of lung neoplasia with review
Patients and methods: We report a case of a 56-year-old male who
underwent total excision of his left lung. An intrabronchal lesion that
obstructed the main left bronchus was observed in the lower lobe. The
lesion was also infiltrating the lung parenchyma and had maximum
dimension 6,5cm. Histological examination revealed a malignant tumor,
consisted mostly of large cells with irregular shape, abundant cytoplasm
and large nuclei. Immunohistochemical results showed that some of
the cells were expressing neuroendocrine markers (chromogranine,
synaptophysine, CD 56) and the rest of them were expressing markers
(p63, Ck5/6) that defined the presence of a squamous cell carcinoma.
Results: According to morphological and immunohistochemical
findings, a diagnosis of a combined large cell neuroendocrine carcinoma
with squamous cell carcinoma of the lung was confirmed.
Conclusions: A research in international literature showed that this
case of combined large cell neuroendocrine carcinoma with squamous
cell carcinoma of the lung is uncommon.
Cite this abstract as: Sekouli A, Cheva A, Tryfon S, Zoglopitis F, Sakkas L.
Combined large cell neuroendocrine CA with squamous cell CA of the lung. J
Thorac Dis 2012;4(S1):AB56. DOI: 10.3978/j.issn.2072-1439.2012.s056